Anti-CD11a / Integrin alphaL / LFA-1 alpha Chain Monoclonal Antibody

Boster Bio Anti-CD11a / Integrin alphaL / LFA-1 alpha Chain Monoclonal Antibody (Catalog # M04466) . Tested in Flow Cytometry, IF, Functional Assay applications. This antibody reacts with Human.

Product Specifications

Background

Recognizes a protein of 180kDa, identified as CD11a (Leucocyte Workshop II; Code N202) . CD11a complex with the 2 subunit of the integrin family, CD18, to form the cell surface heterodimer, LFA-1 or CD11a /C18 (aLbL) . LFA-1 is expressed on all leukocytes including lymphocytes, monocytes, and granulocytes. It is involved in leukocyte adhesion to its ligands including intercellular adhesion molecule-1 (ICAM-1 or CD54), ICAM-2 (CD102), ICAM-3 (CD50) and Telencephalin (TLN) and play a role in most immune/inflammatory responses.

Synonyms

Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a; ITGAL; CD11A

Gene Name

ITGAL

UniProt

P20701

Host

Mouse

Reactivity

Human

Immunogen

Stimulated human leukocytes

Clonality

Monoclonal

Clone

Clone: Clone: CRIS-3

Tissue Specificity

Leukocytes.

Applications

Flow Cytometry, IF, Functional Assay

Field of Research

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

Purification

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

Concentration

Purified antibody with BSA and azide at 200ug/ml

Form

Liquid

Function

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

Molecular Weight

128770 MW

Shipping Conditions

Available

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M04466

Product MSDS

https://www.bosterbio.com/msds?sku=M04466

Fragment

IgG2b, kappa

Other Gene Names

Integrin alpha-L

Subcellular Location

Cell Surface

Curated Selection

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