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Anti-Thymidylate Synthase (5-FU Resistance Marker) TYMS Monoclonal Antibody

Boster Bio Anti-Thymidylate Synthase (5-FU Resistance Marker) TYMS Monoclonal Antibody (Catalog # M04320) . Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human.

Product Specifications

Background

This monoclonal antibody recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45) . TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Synonyms

Thymidylate synthase; TS; TSase;2.1.1.45; TYMS; TS; OK/SW-cl.29

Gene Name

TYMS

UniProt

P04818

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human thymidylate synthase (TS106 & TMS715)

Clonality

Monoclonal

Clone

Clone: Clone: TS106 + TMS715

Applications

Flow Cytometry, IF, IHC

Field of Research

DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathways, Metabolism, Nucleotide Metabolism, Pathways and Processes

Purification

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

Concentration

Purified antibody with BSA and azide at 200ug/ml

Form

Liquid

Function

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. .

Molecular Weight

35716 MW

Shipping Conditions

Available

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M04320

Product MSDS

https://www.bosterbio.com/msds?sku=M04320

Fragment

IgG1, kappa + IgG1, kappa

Other Gene Names

Thymidylate synthase

Subcellular Location

Cytoplasmic and Nuclear

Curated Selection

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