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Anti-RNF20 Rabbit Monoclonal Antibody

Boster Bio Anti-RNF20 Rabbit Monoclonal Antibody catalog # M03457. Tested in WB, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

E3 ubiquitin-protein ligase BRE1A; BRE1-A; hBRE1;6.3.2.-; RING finger protein 20; RNF20; BRE1A

Gene Name

E3 ubiquitin-protein ligase BRE1A

UniProt

Q5VTR2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human RNF20

Clonality

Monoclonal

Clone

Clone: ABC-18

Tissue Specificity

Expressed in the normal brain and also in malignant gliomas (at protein level) . .

Applications

WB, ICC, IF, IP, Flow Cytometry

Field of Research

Cell Biology, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Histones, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ring Finger E3 Ligase, Ubiquitin E3 Enzymes

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1) . H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively) . It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M03457

Product MSDS

https://www.bosterbio.com/msds?sku=M03457

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>ICC/IF 1:50-1:200<br>IP 1:50<br>FC 1:50

Other Gene Names

RNF20

Subcellular Location

Nucleus .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

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