Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-BAG-1L Rabbit Monoclonal Antibody, Clone#RM310

Boster Bio Anti-BAG-1L Rabbit Monoclonal Antibody, Clone#RM310 (Catalog # M02423) . Tested in IHC, WB, ICC applications. This antibody reacts with Human.

Product Specifications

Synonyms

BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1; BAG1; HAP

Gene Name

BAG1

UniProt

Q99933

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human BAG-1L. It does not cross-react to BAG-1M or BAG-1S.

Immunogen

A peptide corresponding to residues near the N-terminus of human BAG-1L

Clonality

Monoclonal

Clone

Clone: RM310

Tissue Specificity

Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level) .

Applications

IHC, WB, ICC

Field of Research

Apoptosis, Apoptotic Markers, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877) . Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406) . Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631) .

Molecular Weight

38779 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M02423

Product MSDS

https://www.bosterbio.com/msds?sku=M02423

Fragment

Rabbit IgG

Other Gene Names

BAG family molecular chaperone regulator 1

Subcellular Location

Isoform 1: Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MAGNETIC BEAD EXTRACTION REPLICATOR, MagPin-G, 96 Magnetic Pins, 48MGO, 3.2mm Diameter, 22mm Long, 9mm Center Spacing, Grooves machined on side for Robot Gripper Mount
VP 407AM-N-GRIP 1 Each

MAGNETIC BEAD EXTRACTION REPLICATOR, MagPin-G, 96 Magnetic Pins, 48MGO, 3.2mm Diameter, 22mm Long, 9mm Center Spacing, Grooves machined on side for Robot Gripper Mount

Ask
View Details
Rabbit Monoclonal OLT-2 Antibody (2564C) [Alexa Fluor 532]
FAB10059X 0.1 mL

Rabbit Monoclonal OLT-2 Antibody (2564C) [Alexa Fluor 532]

Ask
View Details
TEX12 (NM_031275) Human Over-expression Lysate
LC410612 20 µg

TEX12 (NM_031275) Human Over-expression Lysate

Ask
View Details