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Anti-GRP94 / HSP90B1 (Endoplasmic Reticulum Marker) Monoclonal Antibody

Boster Bio Anti-GRP94 / HSP90B1 (Endoplasmic Reticulum Marker) Monoclonal Antibody (Catalog # M02393) . Tested in Flow Cytometry, IF, WB, IHC applications. This antibody reacts with Human, Monkey, Horse, Cow, Sheep, Pig, Rabbit, Dog, Rat, Mouse, Hamster, Guinea pig, Chicken, Xenopus laevis.

Product Specifications

Background

Recognizes a protein of 94kDa, which is identified as the glucose-regulated protein 94 (grp94) and also tumor rejection antigen (gp96) . Grp94 shows a high degree of sequence homology with the heat shock protein 90 (hsp90) . This monoclonal antibody is highly specific to grp94 and shows minimal cross-reaction with other members of the HSP90 family. Grp's are a class of proteins unresponsive to heat shock and are induced by glucose deprivation. Grp94 has been briefly studied as a prognostic factor in breast cancer.

Synonyms

Endoplasmin;94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog; HSP90B1; GRP94, TRA1

Gene Name

HSP90B1

UniProt

P14625

Host

Rat

Reactivity

Human, Monkey, Horse, Cow, Sheep, Pig, Rabbit, Dog, Rat, Mouse, Hamster, Guinea pig, Chicken, Xenopus laevis

Immunogen

Purified glucose regulated protein 94 (grp94) from chicken oviducts

Clonality

Monoclonal

Clone

Clone: Clone: SPM249

Applications

Flow Cytometry, IF, WB, IHC

Field of Research

Cancer, Cancer Metabolism, ER Proteins, Metabolism, Metabolism Processes, Organelles, Pathways and Processes, Protein Trafficking, Response To Hypoxia, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

Concentration

Purified antibody with BSA and azide at 200ug/ml

Form

Liquid

Function

Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity) . Functions in endoplasmic reticulum associated degradation (ERAD) . Has ATPase activity. .

Molecular Weight

92469 MW

Shipping Conditions

Available

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M02393

Product MSDS

https://www.bosterbio.com/msds?sku=M02393

Fragment

IgG2a, kappa

Other Gene Names

Endoplasmin

Subcellular Location

Cytoplasmic and Nuclear

Curated Selection

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