Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Rad21 Rabbit Monoclonal Antibody

Boster Bio Anti-Rad21 Rabbit Monoclonal Antibody catalog # M01864. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Double-strand-break repair protein rad21 homolog; hHR21; Nuclear matrix protein 1; NXP-1; SCC1 homolog; RAD21; HR21, KIAA0078, NXP1

Gene Name

Double-strand-break repair protein rad21 homolog

UniProt

O60216

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Rad21

Clonality

Monoclonal

Clone

Clone: CBH-18

Tissue Specificity

Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. .

Applications

WB, Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Division,2339, Chromosome Structure, DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01864

Product MSDS

https://www.bosterbio.com/msds?sku=M01864

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:1000<br>FC 1:50

Other Gene Names

RAD21

Subcellular Location

Nucleus . Chromosome . Chromosome, centromere . Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis. .

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

7-Acetamido Nitrazepam
TRC-A158470-1MG 1 mg

7-Acetamido Nitrazepam

Ask
View Details
Recombinant Mouse Prolactin-3D1(Prl3d1)
AP77498-01 20 µg

Recombinant Mouse Prolactin-3D1(Prl3d1)

Ask
View Details
Recombinant Mouse Prolactin-3D1(Prl3d1)
AP77498-02 100 µg

Recombinant Mouse Prolactin-3D1(Prl3d1)

Ask
View Details
Recombinant Mouse Prolactin-3D1(Prl3d1)
AP77498-03 1 mg

Recombinant Mouse Prolactin-3D1(Prl3d1)

Ask
View Details
4- (3-Chlorophenyl) -1,7-Diethylpyrido[2,3-d]Pyrimidin-2 (1H) -One
OR1024169-01 100 mg

4- (3-Chlorophenyl) -1,7-Diethylpyrido[2,3-d]Pyrimidin-2 (1H) -One

Ask
View Details
4- (3-Chlorophenyl) -1,7-Diethylpyrido[2,3-d]Pyrimidin-2 (1H) -One
OR1024169-02 250 mg

4- (3-Chlorophenyl) -1,7-Diethylpyrido[2,3-d]Pyrimidin-2 (1H) -One

Ask
View Details