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Anti-MCM7 Monoclonal Antibody

Boster Bio Anti-MCM7 Monoclonal Antibody catalog # M01649-1. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Mucin-16 ; MUC-16; Ovarian cancer-related tumor marker CA125 ; CA-125 ; Ovarian carcinoma antigen CA125 ; MUC16 ; CA125

Gene Name

Mucin-16

UniProt

P33993

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human MCM7 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.

Clonality

Monoclonal

Clone

Clone: BA-13

Tissue Specificity

Expressed in corneal and conjunctival epithelia (at protein level) . Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. .

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01649-1

Product MSDS

https://www.bosterbio.com/msds?sku=M01649-1

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>IHC 1:50-1:200<br>ICC/IF 1:50-1:200<br>IP 1:50<br>FC 1:50

Other Gene Names

MCM7

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

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