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Anti-TRPM8 Monoclonal Antibody

Boster Bio Anti-TRPM8 Monoclonal Antibody catalog # M01002. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

TAR DNA-binding protein 43; TDP-43; TARDBP; TDP43

Gene Name

TAR DNA-binding protein 43

UniProt

Q7Z2W7

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human TRPM8

Clonality

Monoclonal

Clone

Clone: ADBI-20

Tissue Specificity

Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

Applications

WB, ICC, IF

Field of Research

Cancer, Channels, Metabolism, Neuroscience, Plasma Membrane, Sensory System, Signal Transduction

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a interaction with the 3' UTR. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01002

Product MSDS

https://www.bosterbio.com/msds?sku=M01002

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>ICC/IF 1:50-1:200

Other Gene Names

TRPM8

Subcellular Location

Nucleus . In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

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