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Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody

Boster Bio Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody catalog # M00971. Tested in WB, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Synonyms

Histone deacetylase 4; HD4;3.5.1.98; HDAC4; KIAA0288

Gene Name

Histone deacetylase 4

UniProt

P56524

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human HDAC4

Clonality

Monoclonal

Clone

Clone: HGI-8

Tissue Specificity

Ubiquitous.

Applications

WB, ICC, IF

Field of Research

Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M00971

Product MSDS

https://www.bosterbio.com/msds?sku=M00971

Fragment

Rabbit IgG

Applications Notes

WB 1:1000-1:2000<br>ICC/IF 1:50-1:200

Other Gene Names

HDAC4

Subcellular Location

Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

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