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Anti-Integrin alpha 4 ITGA4 Rabbit Monoclonal Antibody

Boster Bio Anti-Integrin alpha 4 ITGA4 Rabbit Monoclonal Antibody catalog # M00468. Tested in WB application. This antibody reacts with Human.

Product Specifications

Synonyms

Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d; ITGA4; CD49D

Gene Name

Integrin alpha-4

UniProt

P13612

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Integrin alpha 4

Clonality

Monoclonal

Clone

Clone: IHH-9

Tissue Specificity

Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Applications

WB

Field of Research

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Immunology, Integrins, Neural Stem Cells, Signal Transduction, Stem Cells, Surface Molecules

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M00468

Product MSDS

https://www.bosterbio.com/msds?sku=M00468

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000

Other Gene Names

ITGA4

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

T-cell surface glycoprotein CD4

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