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Anti-PAX6 Monoclonal Antibody

Boster Bio Anti-PAX6 Monoclonal Antibody (Catalog # M00273) . Tested in ELISA, IF applications. This antibody reacts with Human.

Product Specifications

Background

Paired box protein Pax-6 also known as aniridia type II protein (AN2) or oculorhombin is a transcription factor with key functions in the development of the eye, nose, central nervous system and pancreas. Pax6 further seems to be required for the differentiation of pancreatic islet alpha cells. PAX6 has been shown to bind to a promoter element in the glucagon, insulin and somatostatin promoters and regulates the specification of the ventral neuron subtypes by establishing the correct progenitor domains. Isoform 5a appears to function as a molecular switch that specifies target genes. Anti-PAX6 antibody is ideal for researchers interested in developmental biology, stem cell research, cell growth and cancer research.

Synonyms

Pax6, Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, AN2, PAX 6

Gene Name

PAX6

UniProt

P26367

Host

Mouse

Reactivity

Human

Immunogen

PAX6 protein A purified antibody was prepared in mice by repeated immunizations with a recombinant protein corresponding to human PAX6 protein.

Clonality

Monoclonal

Clone

Clone: Clone: 7H10.D3.D4.G5 IgG1 kappa

Tissue Specificity

Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.

Applications

ELISA, IF

Field of Research

Cell Type Marker, Developmental Biology, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Neural Signal Transduction, Neurology Process, Neuroscience, Organogenesis, Stem Cells, Transcription

Purification

Anti-PAX6 was purified from clarified ascites by Protein A chromatography. Cross-reactivity with PAX6 from other sources has not been determined.

Concentration

1 mg/mL by UV absorbance at 280 nm

Form

Liquid (sterile filtered)

Function

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity) . Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity) . Isoform 5a appears to function as a molecular switch that specifies target genes.

Molecular Weight

46683 MW

Shipping Conditions

Due to dry ice shipping issues, this product is temporarily not available to distributors outside of the United States.

Storage Conditions

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M00273

Product MSDS

https://www.bosterbio.com/msds?sku=M00273

Fragment

IgG1 kappa

Applications Notes

Anti-PAX6 antibody has been tested by ELISA and Immunofluorescence and suitable for Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 46.7 kDa in size corresponding to PAX6 by western blotting in the appropriate cell lysate or extract.

Other Gene Names

Paired box protein Pax-6

Subcellular Location

Nucleus.

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