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Anti-FMRP FMR1 Rabbit Monoclonal Antibody

Boster Bio Anti-FMRP FMR1 Rabbit Monoclonal Antibody catalog # M00192. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Fragile X mental retardation protein 1; FMRP; Protein FMR-1; FMR1

Gene Name

Fragile X mental retardation protein 1

UniProt

Q06787

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human FMRP

Clonality

Monoclonal

Clone

Clone: ABAA-6

Tissue Specificity

Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells. .

Applications

WB, IHC, ICC, IF

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Neural Signal Transduction, Neurology Process, Neuroscience

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity) . RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly (G), binds moderately to poly (U) but shows very little binding to poly (A) or poly (C) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M00192

Product MSDS

https://www.bosterbio.com/msds?sku=M00192

Fragment

Rabbit IgG

Applications Notes

WB 1:500-1:2000<br>IHC 1:50-1:200<br>ICC/IF 1:50-1:200

Other Gene Names

FMR1

Subcellular Location

Cytoplasm . Nucleus . Nucleus, nucleolus .

Protein Name

P2X purinoceptor 1

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