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Anti-c-Myc Oncoprotein Monoclonal Antibody

Boster Bio Anti-c-Myc Oncoprotein Monoclonal Antibody (Catalog # M00026) . Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human.

Product Specifications

Background

This monoclonal antibody recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This monoclonal antibody shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.

Synonyms

Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64; MYC; BHLHE39

Gene Name

MYC

UniProt

P01106

Host

Mouse

Reactivity

Human

Immunogen

A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc, coupled to KLH.

Clonality

Monoclonal

Clone

Clone: Clone: SPM237

Applications

Flow Cytometry, IF, IHC

Field of Research

Cancer, Cell Cycle, Cell Differentiation, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Nuclear, Oncoproteins, Oncoproteins/Suppressors, Signaling Pathways, Stem Cells, TGF Beta, Transcription, Transcription Factors, Tumor Biomarkers

Purification

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

Concentration

Purified antibody with BSA and azide at 200ug/ml

Form

Liquid

Function

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes.

Molecular Weight

48804 MW

Shipping Conditions

Available

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M00026

Product MSDS

https://www.bosterbio.com/msds?sku=M00026

Fragment

IgG1, kappa

Other Gene Names

Myc proto-oncogene protein

Subcellular Location

Nuclear

Curated Selection

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