α2A-AR agonist 1
Product Specifications
UNSPSC Description
α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes[1].
Target Antigen
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/α2a-ar-agonist-1.html
Smiles
BrC1=C(C2=CC=C1)OCCC2C3=CNC=N3
Molecular Weight
279.13
References & Citations
[1]Lv X, et al., Designing Chromane Derivatives as α2A-Adrenoceptor Selective Agonists via Conformation Constraint. J Med Chem. 2024 Jun 18.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162620/α2A-AR-agonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162620/
Clinical Information
No Development Reported
CAS Number
2971825-58-6
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
41313121 3 x 1.0μg DNA
RPL29P24 CRISPRa sgRNA lentivector (set of three targets)(Human)
Ask
View Details 