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Anti-C14orf49 Antibody

Boster Bio Anti-C14orf49 Antibody (Catalog # A13164) . Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.<br><br>Li W.B., Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.<br>Heilig R., Nature 421:601-607(2003).<br>Ota T., Nat. Genet. 36:40-45(2004).

Synonyms

Nesprin-3; Nuclear envelope spectrin repeat protein 3; SYNE3; C14orf49

Gene Name

SYNE3

UniProt

Q6ZMZ3

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human C14orf49.

Clonality

Polyclonal

Tissue Specificity

Expressed in aortic endothelial cells (at protein level) . .

Applications

WB

Field of Research

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells. .

Molecular Weight

112216 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A13164

Product MSDS

https://www.bosterbio.com/msds?sku=A13164

Other Gene Names

Nesprin-3

Subcellular Location

Nucleus outer membrane ; Single-pass type IV membrane protein . Nucleus envelope . Rough endoplasmic reticulum .

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