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Anti-COBRA1 (NELF B) Antibody

Boster Bio Anti-COBRA1 (NELF B) Antibody (Catalog # A12025) . Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004) . COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004)

Synonyms

A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Cofactor of BRCA1 antibody, DKFZp586B0519 antibody, KIAA1182 antibody, Negative elongation factor B antibody, Negative elongation factor protein B antibody, Nelf b antibody, NELF-B antibody, NELFB antibody, RGD1307832 antibody, RP13-122B23.3 antibody, RP23-132N23.4 antibody

Gene Name

COBRA1

UniProt

Q8WX92

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant full length human COBRA1 purified from E. coli. Immunogen species is Human.

Clonality

Monoclonal

Clone

Clone: F7E4

Tissue Specificity

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.

Applications

WB

Field of Research

Epigenetics and Nuclear Signaling, Transcription

Purification

Protein G purified culture supernatant.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

WB: 1:1000

Form

Liquid

Function

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding.

Molecular Weight

65697 MW

Shipping Conditions

Available

Storage Conditions

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year. After date of receipt, stable for at least 1 year at -20°C.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A12025

Product MSDS

https://www.bosterbio.com/msds?sku=A12025

Fragment

IgG1

Applications Notes

Specific for endogenous levels of the ~62 kDa COBRA1 protein.

Other Gene Names

Negative elongation factor B

Subcellular Location

Nucleus.

Protein Name

Negative elongation factor B

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