Anti-synaptophysin 2 Synpr Antibody

Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). <br> <br> Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4. <br> Valtorta, F. et al. (2004) Bioessays 26, 445-53. <br> Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14. <br> Bonanomi, D. et al. (2007) Biochem J 404, 525-34.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.