Anti-MRPL12 Antibody

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.<br><br>Marty L., J. Biol. Chem. 271:11468-11476(1996).<br>Liu J., Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.<br>The MGC Project Team; Genome Res. 14:2121-2127(2004).

DNA/RNA, Epigenetics and Nuclear Signaling, Metabolism, Mito. Translation, Mitochondria, Mitochondrial Markers, Mitochondrial Metabolism, Organelles, Pathways and Processes, Ribosome, Subcellular Markers, Tags & Cell Markers, Translation