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Anti-MED21/Srb7 Antibody

Boster Bio Anti-MED21/Srb7 Antibody (Catalog # A10271) . Tested in IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<br><br>Chao D.M., Nature 380:82-85(1996).<br>Maldonado E., Nature 381:86-89(1996).<br>Oelgeschlaeger T., Mol. Cell 1:925-931(1998).

Synonyms

Mediator of RNA polymerase II transcription subunit 21; Mediator complex subunit 21; RNA polymerase II holoenzyme component SRB7; RNAPII complex component SRB7; hSrb7; MED21; SRB7, SURB7

Gene Name

MED21

UniProt

Q13503

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human MED21.

Clonality

Polyclonal

Applications

IHC

Field of Research

Epigenetics and Nuclear Signaling, Mediator Complex, Pol II Transcription, Polymerase Associated Factors, RNA Polymerase, Transcription

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1:50~1:100

Form

Liquid

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

Molecular Weight

15564 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A10271

Product MSDS

https://www.bosterbio.com/msds?sku=A10271

Other Gene Names

Mediator of RNA polymerase II transcription subunit 21

Subcellular Location

Nucleus .

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