Anti-Acyl-coenzyme A thioesterase 8 ACOT8 Antibody

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs By similarity. May be involved in the metabolic regulation of peroxisome proliferation.<br><br>Watanabe H., Biochem. Biophys. Res. Commun. 238:234-239(1997).<br>Liu L.X., J. Biol. Chem. 272:13779-13785(1997).<br>Jones J.M., J. Biol. Chem. 274:9216-9223(1999).

Acyl-coenzyme A thioesterase 8; Acyl-CoA thioesterase 8;3.1.2.27 ; Choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; Peroxisomal long-chain acyl-CoA thioesterase 1; Thioesterase II; hACTE-III; hACTEIII; hTE; ACOT8; ACTEIII, PTE1, PTE2

Antiviral Signaling, Cancer, Cancer Metabolism, Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Immune System Diseases, Immunology, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Organelles, Pathways and Processes, Redox Metabolism, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431) . Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA) . Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233) . Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233) . Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431) . .