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Anti-UBQLN4/A1Up Antibody

Boster Bio Anti-UBQLN4/A1Up Antibody (Catalog# A08887) . Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

UBQLN4; C1orf6; CIP75; UBIN; Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75

Gene Name

UBQLN4

UniProt

Q9NRR5

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A peptide derived from human UBQLN4. Immunogen sequence location: 201 - 250

Clonality

Polyclonal

Tissue Specificity

Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.

Applications

WB, IHC-P, IF (paraffin), ELISA

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ub-Like Proteins

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS) . Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6) . Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity) . Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) .

Molecular Weight

63853 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A08887

Product MSDS

https://www.bosterbio.com/msds?sku=A08887

Fragment

Rabbit IgG

Other Gene Names

Ubiquilin-4

Subcellular Location

Nucleus. Cytoplasm. Endoplasmic reticulum. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome. Colocalizes with the proteasome, both in nucleus and cytoplasm.
Curated Selection

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