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Anti-Ik3-1 CABLES1 Antibody

Boster Bio Anti-Ik3-1 CABLES1 Antibody (Catalog # A08581) . Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death By similarity.<br><br>Ota T., Nat. Genet. 36:40-45(2004).<br>Nusbaum C., Nature 437:551-555(2005).<br>Wu C.-L., Cancer Res. 61:7325-7332(2001).

Synonyms

CDK5 and ABL1 enzyme substrate 1; Interactor with CDK3 1; Ik3-1; CABLES1; CABLES

Gene Name

CABLES1

UniProt

Q8TDN4

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human Ik3-1.

Clonality

Polyclonal

Tissue Specificity

Expressed in breast, pancreas, colon, head and neck (at protein level) . Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. .

Applications

WB

Field of Research

Cell Biology, Cell Cycle, Kinases/Phosphatases

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) . .

Molecular Weight

67599 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A08581

Product MSDS

https://www.bosterbio.com/msds?sku=A08581

Other Gene Names

CDK5 and ABL1 enzyme substrate 1

Subcellular Location

Nucleus . Cytoplasm . Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity) . .
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