Anti-DHRS4 Antibody

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones By similarity.<br><br>Fransen M., Biochem. J. 340:561-568(1999).<br>Furukawa A., Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.<br>Du J., Yi Chuan Xue Bao 31:661-667(2004).

Dehydrogenase/reductase SDR family member 4;1.1.1.184; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD; SCAD-SRL; Short chain dehydrogenase/reductase family 25C member 2; Short-chain dehydrogenase/reductase family member 4; DHRS4; SDR25C2; UNQ851/PRO1800

Isoform 1 is predominantly expressed in normal cervix (at protein level) . Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level) . Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity) . .