Anti-EIF3K Antibody

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. HAMAP-Rule MF_03010<br><br>Mayeur G.L., Eur. J. Biochem. 270:4133-4139(2003).<br>Nawa G., Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.<br>Ye M., Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.

Eukaryotic translation initiation factor 3 subunit K ; eIF3k ; Eukaryotic translation initiation factor 3 subunit 12 ; Muscle-specific gene M9 protein; PLAC-24; eIF-3 p25 ; eIF-3 p28; EIF3K ; EIF3S12 ; ARG134, HSPC029, MSTP001, PTD001

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.