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Anti-DIA-2 DIAPH2 Antibody

Boster Bio Anti-DIA-2 DIAPH2 Antibody (Catalog # A07378) . Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Background

DIA-2 (also called DIA drome, Dia2, DIAPH2, Diaphanous 2, Diaphanous related formin 2, Diaphorase 2, DRF2, POF and POF2) may play a role in the development and normal function of the ovaries. Mutations of this gene have been linked to premature ovarian failure. Alternative splicing results in two protein isoforms. Furthermore, each splice variant undergoes additional splicing in the 3' UTR. Overall 4 splice variants have been described. DIA-2 is expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes and can be found from E16 in ovary and testis and during P6-P16 during differentiation of ovarian follicles. Isoform 1 is referred to as DIA-156, whereas isoform 2 is called DIA-12C.

Synonyms

DIA-2, DIA 2, DIA drome, DIA2, DIAPH2, Diaphanous 2, Diaphanous related formin 2, Diaphorase 2, DRF2, POF, POF2

Gene Name

DIAPH2

UniProt

O60879

Host

Rabbit

Reactivity

Human

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues at the C-Terminus of Human DIA-2.

Clonality

Polyclonal

Tissue Specificity

Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.

Applications

ELISA, WB

Field of Research

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Protein Trafficking, Signal Transduction, Vesicle Transport

Purification

This affinity purified antibody is directed against human DIA-2. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from human based on 100% homology for the immunogen sequence. However, cross-reactivity is expected with mouse DIA-2 based on a 93% homology to the immunogen sequence. Cross-reactivity with DIA-2 homologues from other sources has not been determined.

Concentration

1.4 mg/mL by UV absorbance at 280 nm

Form

Liquid (sterile filtered)

Function

Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.

Molecular Weight

125569 MW

Shipping Conditions

Due to dry ice shipping issues, this product is temporarily not available to distributors outside of the United States.

Storage Conditions

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A07378

Product MSDS

https://www.bosterbio.com/msds?sku=A07378

Fragment

IgG

Applications Notes

This affinity purified antibody has been tested for use in ELISA and by western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 125 kDa in size corresponding to DIA-2 by western blotting in the appropriate cell lysate or extract. Alternate splice variants have been described for this protein. This antibody will only react with DIA-156 (isoform 1 of DIA-2) .

Other Gene Names

Protein diaphanous homolog 2

Subcellular Location

Isoform 3: Cytoplasm, cytosol. Early endosome. Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.

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