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Anti-CDCA2 Antibody

Boster Bio Anti-CDCA2 Antibody (Catalog # A07293) . Tested in WB applications. This antibody reacts with Human.

Product Specifications

Background

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.<br><br>Walker M.G., Curr. Cancer Drug Targets 1:73-83(2001).<br>Ota T., . Genet. 36:40-45(2004).<br>Olsen J.V., Cell 127:635-648(2006).

Synonyms

Cell division cycle-associated protein 2; Recruits PP1 onto mitotic chromatin at anaphase protein; Repo-Man; CDCA2

Gene Name

CDCA2

UniProt

Q69YH5

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from C-terminal of human CDCA2.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. .

Applications

WB

Field of Research

Apoptosis, Cancer, Cell Biology, Cell Cycle, Cell Death, Cell Division, Chromatin Modifying Enzymes, Chromosome Structure, Epigenetics and Nuclear Signaling, Metabolism, Metabolism Processes, Nuclear, Pathways and Processes

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. .

Molecular Weight

112676 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A07293

Product MSDS

https://www.bosterbio.com/msds?sku=A07293

Other Gene Names

Cell division cycle-associated protein 2

Subcellular Location

Nucleus . Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
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