Anti-RAB3GAP2 Antibody

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.<br><br>Nagano F., J. Biol. Chem. 273:24781-24785(1998).<br>Xu X., Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.<br>Nagase T., DNA Res. 5:355-364(1998).

Rab3 GTPase-activating protein non-catalytic subunit; RGAP-iso; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP150; Rab3-GAP regulatory subunit; RAB3GAP2; KIAA0839

Developmental Biology, G Protein Signaling, Nervous System Development, Neurogenesis, Neurology Process, Neuroscience, Neurotransmission, Organogenesis, Protein Trafficking, Regulators, Secretory Vesicles, Signal Transduction, Signaling Pathway, Small G Proteins, Vesicle Transport

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D) . Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters. .