Anti-CCL14/Hcc 1 Antibody

C-C motif chemokine 14; Chemokine CC-1/CC-3; HCC-1/HCC-3; HCC-1 (1-74) ; NCC-2; Small-inducible cytokine A14; HCC-1 (3-74) ; HCC-1 (4-74) ; HCC-1 (9-74) ; CCL14; NCC2, SCYA14

Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma. .

Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca (2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1 (9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. .