Anti-HAND1 Antibody
Boster Bio Anti-HAND1 Antibody (Catalog # A06496) . Tested in IF applications. This antibody reacts with Human.
Product Specifications
Background
Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) By similarity.<br><br>Knoefler M., Gene 224:77-86(1998).<br>The MGC Project Team, Genome Res. 14:2121-2127(2004).
Synonyms
Heart- and neural crest derivatives-expressed protein 1; Class A basic helix-loop-helix protein 27; bHLHa27; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND; HAND1; BHLHA27, EHAND
Gene Name
HAND1
UniProt
O96004
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from internal of human HAND1.
Clonality
Polyclonal
Tissue Specificity
Heart.
Applications
IF
Field of Research
Cardiogenesis, Cardiovascular, Developmental Biology, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Stem Cells, Transcription, Transcription Factors/Regulators
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
Immunofluorescence: 1:100~1:500
Form
Liquid
Function
Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box) (By similarity) . .
Molecular Weight
23627 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A06496
Product MSDS
https://www.bosterbio.com/msds?sku=A06496
Other Gene Names
Heart- and neural crest derivatives-expressed protein 1
Subcellular Location
Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity) . .
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