Anti-ICK Antibody

Boster Bio Anti-ICK Antibody (Catalog # A06270) . Tested in IHC, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

May play a key role in the development of multiple organ systems and particularly in cardiac development By similarity.<br><br>Togawa K., J. Cell. Physiol. 183:129-139(2000).<br>Mungall A.J., Nature 425:805-811(2003).<br>Nagase T., DNA Res. 6:63-70(1999).

Synonyms

Serine/threonine-protein kinase ICK;2.7.11.22; Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK; ICK; KIAA0936

Gene Name

ICK

UniProt

Q9UPZ9

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human ICK.

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. .

Applications

IHC, IF

Field of Research

Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling, Kinases/Phosphatases

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Required for ciliogenesis (PubMed:24797473) . Phosphorylates KIF3A (By similarity) . Involved in the control of ciliary length (PubMed:24853502) . Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity) . May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity) . Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity) . .

Molecular Weight

71427 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A06270

Product MSDS

https://www.bosterbio.com/msds?sku=A06270

Other Gene Names

Serine/threonine-protein kinase ICK

Subcellular Location

Nucleus . Cytoplasm, cytosol . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Also found at the ciliary tip (PubMed:24797473) . Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360) . .