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Anti-SH2D2A Antibody

Boster Bio Anti-SH2D2A Antibody (Catalog # A06232) . Tested in WB applications. This antibody reacts with Human.

Product Specifications

Background

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.<br><br>Spurkland A., J. Biol. Chem. 273:4539-4546(1998).<br>Wu L.-W., J. Biol. Chem. 275:6059-6062(2000).<br>Lee J.-S., Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.

Synonyms

SH2 domain-containing protein 2A; SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein; SH2D2A; SCAP, TSAD, VRAP

Gene Name

SH2D2A

UniProt

Q9NP31

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human SH2D2A.

Clonality

Polyclonal

Tissue Specificity

Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.

Applications

WB

Field of Research

Adapters, Adaptive Immunity, Autoimmune, Cancer, Cytoplasmic, Growth Factors, Immune System Diseases, Immunology, Non-CD, Signal Transduction, T Cells

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.

Molecular Weight

42934 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A06232

Product MSDS

https://www.bosterbio.com/msds?sku=A06232

Other Gene Names

SH2 domain-containing protein 2A

Subcellular Location

Cytoplasm.

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