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Anti-ZIC1/2/3 Antibody

Boster Bio Anti-ZIC1/2/3 Antibody (Catalog # A05537) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' By similarity.<br><br>Yokota N., Cancer Res. 56:377-383(1996).

Synonyms

Zinc finger protein ZIC 1; Zinc finger protein 201; Zinc finger protein of the cerebellum 1; ZIC1; ZIC, ZNF201

Gene Name

ZIC1

UniProt

Q15915

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human ZIC1/2/3.

Clonality

Polyclonal

Tissue Specificity

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. .

Applications

WB, IHC

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Neural Signal Transduction, Neurology Process, Neuroscience, Transcription, Zinc Finger

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN) . Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity) . .

Molecular Weight

48309 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A05537

Product MSDS

https://www.bosterbio.com/msds?sku=A05537

Other Gene Names

Zinc finger protein ZIC 1

Subcellular Location

Nucleus. Cytoplasm . Localizes in the cytoplasm in presence of MDFIC overexpression. .

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