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Anti-Cytochrome P450 8B1 CYP8B1 Antibody

Boster Bio Anti-Cytochrome P450 8B1 CYP8B1 Antibody (Catalog # A05518) . Tested in WB, IHC applications. This antibody reacts with Human.

Product Specifications

Background

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.<br><br>Gaafvels M., Genomics 56:184-196(1999).<br>Ota T., Nat. Genet. 36:40-45(2004).<br>Muzny D.M., Nature 440:1194-1198(2006)

Synonyms

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase;1.14.18.8 ;7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; CYPVIIIB1; Cytochrome P450 8B1; Sterol 12-alpha-hydroxylase; CYP8B1; CYP12

Gene Name

CYP8B1

UniProt

Q9UNU6

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human Cytochrome P450 8B1.

Clonality

Polyclonal

Tissue Specificity

Liver.

Applications

WB, IHC

Field of Research

Cardiovascular, Cytochromes, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. .

Molecular Weight

58068 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A05518

Product MSDS

https://www.bosterbio.com/msds?sku=A05518

Other Gene Names

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

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