Anti-GANP MCM3AP Antibody

Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.<br><br>Nobuo Sakaguchi, J. Immunol., Apr 2005; 174: 4485 - 4494.<br>Kazuhiko Kuwahara, Blood, Apr 2000; 95: 2321 - 2328.<br>Y Kono, K Maeda, Genes Cells, Aug 2002; 7: 821 - 834.<br>Kazuhiko Kuwahara, PNAS, Aug 2001; 98: 10279.

Germinal-center associated nuclear protein; GANP;80 kDa MCM3-associated protein; MCM3 acetylating protein; MCM3AP;2.3.1.-; MCM3 acetyltransferase; MCM3AP; GANP, KIAA0572, MAP80

Isoform GANP: Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity) . Involved in the nuclear export of poly (A) -containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket) . TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. .

Isoform GANP: Cytoplasm. Nucleus envelope. Nucleus, nuclear pore complex. In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene. .