Anti-ASPSCR1/Tug Antibody

Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution. <br><br>Ladanyi, M. et al. (2001) Oncogene 20, 48-57. <br>Bogan, J.S. et al. (2003) Nature 425, 727-33. <br>Yu, C. et al. (2007) J Biol Chem 282, 7710-22.

Tether containing UBX domain for GLUT4; Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9; ASPSCR1; ASPL, RCC17, TUG, UBXD9, UBXN9

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity) . Enhances VCP methylation catalyzed by VCPKMT. .

Endomembrane system ; Peripheral membrane protein . Endoplasmic reticulum- Golgi intermediate compartment membrane ; Peripheral membrane protein. Cytoplasm . Nucleus .