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Anti-NTE PNPLA6 Antibody

Boster Bio Anti-NTE PNPLA6 Antibody catalog # A04071. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Patatin-like phospholipase domain containing 6 (PNPLA6), also known as Neuropathy target esterase (NTE), is a human gene. Neuropathy target esterase (NTE) is involved in neural development and is the target for neurodegeneration induced by selected organophosphorus pesticides and chemical warfare agents. The genetic or chemical reduction of Nte activity results in a neurological phenotype of hyperactivity in mammals and indicate that EOPF toxicity occurs directly through inhibition of Nte without the requirement for Nte gain of function or aging.

Synonyms

Neuropathy target esterase;3.1.1.5; Patatin-like phospholipase domain-containing protein 6; PNPLA6; NTE

Gene Name

PNPLA6

UniProt

Q8IY17

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human PNPLA6. AA range:1031-1080

Tissue Specificity

Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain. .

Applications

WB, IHC

Purification

Immunogen affinity purified

Form

Liquid

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho) . This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. .

Molecular Weight

149995 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04071

Product MSDS

https://www.bosterbio.com/msds?sku=A04071

Fragment

IgG

Other Gene Names

Neuropathy target esterase

Subcellular Location

Endoplasmic reticulum membrane ; Single-pass type I membrane protein ; Cytoplasmic side . Anchored to the cytoplasmic face of the endoplasmic reticulum by its N-terminal transmembrane segment. .
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