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Anti-Glycine receptor subunit beta GLRB Antibody

Boster Bio Anti-Glycine receptor subunit beta GLRB Antibody (Catalog # A04017) . Tested in WB applications. This antibody reacts with Human.

Product Specifications

Background

The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).<br><br>Handford C.A., Brain Res. Mol. Brain Res. 35:211-219(1996).<br>Milani N., Genomics 50:341-345(1998).<br>Ota T., Nat. Genet. 36:40-45(2004).

Synonyms

Glycine receptor subunit beta; Glycine receptor 58 kDa subunit; GLRB

Gene Name

GLRB

UniProt

P48167

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human GLRB.

Clonality

Polyclonal

Applications

WB

Field of Research

Ligand-Gated Ion Channels, Neural Signal Transduction, Neurology Process, Neuroscience, Neurotransmission, Receptors / Channels

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346) . Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357) . Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346) . Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488) . .

Molecular Weight

56122 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04017

Product MSDS

https://www.bosterbio.com/msds?sku=A04017

Other Gene Names

Glycine receptor subunit beta

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell projection, dendrite . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523) . Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. .
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