Anti-Rab 35 Antibody
Boster Bio Anti-Rab 35 Antibody catalog # A03845. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Ras-related protein Rab-35; GTP-binding protein RAY; Ras-related protein Rab-1C; RAB35; RAB1C, RAY
Gene Name
RAB35
UniProt
Q15286
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human RAB35. AA range:99-148
Applications
WB
Purification
Immunogen affinity purified
Form
Liquid
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. .
Molecular Weight
23025 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A03845
Product MSDS
https://www.bosterbio.com/msds?sku=A03845
Fragment
IgG
Other Gene Names
Ras-related protein Rab-35
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Membrane, clathrin-coated pit . Cytoplasmic vesicle, clathrin- coated vesicle . Endosome . Melanosome . Present on sorting endosomes and recycling endosome tubules (PubMed:16950109) . Tends to be enriched in PIP2-positive cell membrane domains (PubMed:16950109) . During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis (PubMed:16950109) . Identified in stage I to stage IV melanosomes (PubMed:17081065) . .
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