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Anti-Adrenergic Receptor alpha-2B ADRA2B Antibody

Boster Bio Anti-Adrenergic Receptor alpha-2B ADRA2B Antibody (Catalog # A03622) . Tested in IF applications. This antibody reacts with Human.

Product Specifications

Background

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.<br><br>Lomasney J.W., Proc. Natl. Acad. Sci. U.S.A. 87:5094-5098(1990).<br>Weinshank R.L., Mol. Pharmacol. 38:681-688(1990).<br>Small K.M., J. Biol. Chem. 276:4917-4922(2001).

Synonyms

Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2BAR; ADRA2B; ADRA2L1, ADRA2RL1

Gene Name

ADRA2B

UniProt

P18089

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human Adrenergic Receptor alpha-2B.

Clonality

Polyclonal

Applications

IF

Field of Research

G Protein Signaling, Growth Factors/Hormones, Signal Transduction, Signaling Pathway

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Immunofluorescence: 1:100~1:500

Form

Liquid

Function

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. .

Molecular Weight

49566 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03622

Product MSDS

https://www.bosterbio.com/msds?sku=A03622

Other Gene Names

Alpha-2B adrenergic receptor

Subcellular Location

Cell membrane ; Multi-pass membrane protein . Interaction with RAB26 mediates transport from the Golgi to the cell membrane.

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