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Anti-UBR1 Antibody

Boster Bio Anti-UBR1 Antibody (Catalog # A03250) . Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.<br><br>Kwak K.S., Cancer Res. 64:8193-8198(2004).<br>Dgany O., Am. J. Hum. Genet. 71:1467-1474(2002).<br>Ota T., Nat. Genet. 36:40-45(2004).

Synonyms

E3 ubiquitin-protein ligase UBR1;6.3.2.-; N-recognin-1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I; UBR1

Gene Name

UBR1

UniProt

Q8IWV7

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from internal of human UBR1.

Clonality

Polyclonal

Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level) . .

Applications

WB

Field of Research

Cell Biology, Proteasome, Proteasome / Ubiquitin, Proteolysis/Ubiquitin

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. .

Molecular Weight

200211 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03250

Product MSDS

https://www.bosterbio.com/msds?sku=A03250

Other Gene Names

E3 ubiquitin-protein ligase UBR1

Subcellular Location

Cytoplasm, cytosol .

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