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Anti-p62Dok (Ab-398) DOK1 Antibody

Boster Bio Anti-p62Dok (Ab-398) DOK1 Antibody (Catalog # A03039) . Tested in WB, IHC, IF applications. This antibody reacts with Human.

Product Specifications

Background

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. <br><br>Michael J. Wick, et, al. (2001) J. Biol. Chem; 276: 42843 - 42850. <br>Paul D. Simoncic, et, al. (2006) Mol. Cell. Biol; 26: 4149 - 4160. <br>Nadia Dub

Synonyms

Docking protein 1; Downstream of tyrosine kinase 1; p62 (dok) ; pp62; DOK1

Gene Name

DOK1

UniProt

Q99704

Host

Rabbit

Reactivity

Human

Immunogen

Peptide sequence around aa.396~400 (P-I-Y-D-E) derived from Human p62Dok.

Clonality

Polyclonal

Tissue Specificity

Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. .

Applications

WB, IHC, IF

Field of Research

Adapters, Cancer, Cardiovascular, Cytoplasmic, G Protein Signaling, Lipid Signaling, Metabolism, Obesity, Platelets, Protein Phosphorylation, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins, Tyrosine Kinases

Purification

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/ml

Form

Liquid

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. .

Molecular Weight

52392 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03039

Product MSDS

https://www.bosterbio.com/msds?sku=A03039

Other Gene Names

Docking protein 1

Subcellular Location

Isoform 1: Cytoplasm. Nucleus.

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