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Anti-TRADD Antibody

Boster Bio Anti-TRADD Antibody (Catalog # A02785) . Tested in WB, IHC applications. This antibody reacts with Human.

Product Specifications

Background

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARFof CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARFof CDKN2A By similarity. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.<br><br>Hiroyasu Inada, J. Cell Biol., Oct 2001; 155: 415. <br>Kenneth M. Izumi, Mol. Cell. Biol., Aug 1999; 19: 5759 - 5767. <br>Susumu Rokudai, Mol. Cell. Biol., Dec 2002; 22: 8695 - 8708.

Synonyms

Tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; TRADD

Gene Name

TRADD

UniProt

Q15628

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from Internal of human TRADD.

Clonality

Polyclonal

Tissue Specificity

Found in all examined tissues.

Applications

WB, IHC

Field of Research

Apoptosis, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Cell Death, Invasion/Microenvironment, Receptors, Vascular Inflammation

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity) . Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. .

Molecular Weight

34247 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A02785

Product MSDS

https://www.bosterbio.com/msds?sku=A02785

Other Gene Names

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Subcellular Location

Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Shuttles between the cytoplasm and the nucleus. .

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