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Anti-Granzyme B GZMB Antibody

Boster Bio Anti-Granzyme B GZMB Antibody (Catalog # A00353) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.<br><br>David A. Jans, J. Biol. Chem., Nov 1996; 271: 30781.<br>Eugene Estella, Diabetes, Aug 2006; 55: 2212 - 2219.<br>Yong Gu, J. Biol. Chem., May 1996; 271: 10816.<br>Jiuru Sun, J. Biol. Chem., Nov 1996; 271: 27802.

Synonyms

Granzyme B;3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMB; CGL1, CSPB, CTLA1, GRB

Gene Name

GZMB

UniProt

P10144

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human Granzyme B.

Clonality

Polyclonal

Applications

WB, IHC

Field of Research

Adaptive Immunity, Apoptosis, Cell Biology, Immunology, Innate Immunity, NK Cells, T Cells

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Molecular Weight

27716 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00353

Product MSDS

https://www.bosterbio.com/msds?sku=A00353

Other Gene Names

Granzyme B

Subcellular Location

Cytoplasmic granule . Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

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