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Human IDS/Iduronate 2 Sulfatase ELISA Kit PicoKine®

Human IDS/Iduronate 2 Sulfatase ELISA Kit PicoKine® (96 Tests) . Quantitate Human IDS in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) . Sensitivity: 15pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

Product Specifications

Background

Iduronate 2-sulfatase (IDS) is a sulfatase enzyme associated with Hunter syndrome. It encodes a member of the sulfatase family of proteins. Iduronate 2-sulfatase is involved in the lysosomal degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Synonyms

Iduronate 2-sulfatase;3.1.6.13; Alpha-L-iduronate sulfate sulfatase; Idursulfase; Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain; IDS; SIDS

Gene Name

Iduronate 2-sulfatase

UniProt

P22304

Reactivity

Human

Cross Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Immunogen

Expression system for standard: NS0; Immunogen sequence: S26-P550

Tissue Specificity

Liver, kidney, lung, and placenta.

Applications

ELISA

Sample Type

Cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) .

Detection Range

156 pg/ml - 10,000 pg/ml

Sensitivity

<15 pg/ml

Function

Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

Storage Conditions

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EK1452

Product MSDS

https://www.bosterbio.com/msds?sku=EK1452

Other Gene Names

IDS

Subcellular Location

Lysosome.

Protein Name

Iduronate 2-sulfatase

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