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Human CD320 / 8D6A / TCblR ELISA Kit PicoKine®

Human CD320 / 8D6A / TCblR ELISA Kit PicoKine® (96 Tests) . Quantitate Human CD320 in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

Product Specifications

Background

CD320 (cluster of differentiation 320), also known as 8D6A or TCBLR, is a human gene. It is mapped to chromosome 19p13.2. This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and the expression of CD320 enhanced B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. It has been found that antagonists of the CD320 signaling pathway may counter the growth of follicular lymphomas or other tumors that metastasize to lymphoid follicles. CD320 is also a specific receptor for uptake of TCN2-bound cobalamin.

Synonyms

CD320 antigen;8D6 antigen; FDC-signaling molecule 8D6; FDC-SM-8D6; Transcobalamin receptor; TCblR; CD320; CD320;8D6A; UNQ198/PRO224

Gene Name

CD320 antigen

UniProt

Q9NPF0

Reactivity

Human

Cross Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Immunogen

Expression system for standard: NS0; Immunogen sequence: S36-Y229

Tissue Specificity

Expressed abundantly on follicular dendritic cells (FDCs) . .

Applications

ELISA

Field of Research

Adaptive Immunity, B Cells, Cell Biology, Cell Cycle, Cell Differentiation, Developmental Biology, Immunology, Organogenesis

Sample Type

Cell culture supernatants, serum, plasma (heparin, EDTA) and urine.

Detection Range

156 pg/ml - 10,000 pg/ml

Sensitivity

<10 pg/ml

Function

Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) . CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin. .

Storage Conditions

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EK1255

Product MSDS

https://www.bosterbio.com/msds?sku=EK1255

Other Gene Names

CD320

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

CD320 antigen

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