Mouse WISP1/CCN4 ELISA Kit PicoKine®

WISP1 (WNT1-Inducible Signaling Pathway Protein 1), also known as CCN4, is a matricellular protein that in humans is encoded by the WISP1 gene. WISP1 is induced by WNT1 and belongs to the CCN family, which includes connective tissue growth factor, cysteine-rich-61, and nephroblastoma overexpressed. By use of radiation hybrid mapping panels, the WISP1 was mapped to chromosome 8q24.1-q24.3, roughly 4 Mb distal to MYC. It found that 2 distinct systems demonstrated that WISP induction was associated with expression of WNT1. WISP1 genomic DNA was amplified in colon cancer cell lines and in human colon tumors, and its RNA was overexpressed in 84% of tumors examined compared with patient-matched normal mucosa.

Highly expressed in kidney and lung. Lower levels in heart, brain, spleen, liver, skeletal muscle and testis. Expressed in low metastatic melanoma cells.

Developmental Families, DNA/RNA, DNA Damage & Repair, DNA Damage Response, Domain Families, Epigenetics and Nuclear Signaling, Secreted, Signaling Pathways, Stem Cells, Transcription

Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity) . Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity) . In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity) . Suppresses tumor growth in vivo. .

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)