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Human KLK5/Kallikrein-5 ELISA Kit PicoKine®

Human KLK5/Kallikrein 5 ELISA Kit PicoKine® (96 Tests) . Quantitate Human KLK5 in cell culture supernatants, serum, plasma (heparin, EDTA), human milk and saliva. Sensitivity: 10pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

Product Specifications

Background

Kallikrein gene 5 (KLK5, also known as KLK-L2), located on chromosome 19q13.4, is one of the newly identified members of the kallikrein gene family, which is a subgroup of the serine protease enzyme family. In normal human tissues, KLK5 is highly expressed in skin, mammary gland and testis. KLK5 has been suggested to regulate cell shedding (desquamation) in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. It is proposed that KLK5 regulates this process since it is able to self-activate in addition to activating KLK7 and KLK14.

Synonyms

Kallikrein-5;3.4.21.-; Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme; KLK5; SCTE; UNQ570/PRO1132

Gene Name

Kallikrein-5

UniProt

Q9Y337

Reactivity

Human

Cross Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Immunogen

Expression system for standard: NS0; Immunogen sequence: V23-S293

Tissue Specificity

Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin. .

Applications

ELISA

Field of Research

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Sample Type

Cell culture supernatants, serum, plasma (heparin, EDTA), human milk and saliva.

Detection Range

78 pg/ml - 5,000 pg/ml

Sensitivity

<10 pg/ml

Function

May be involved in desquamation.

Storage Conditions

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EK0817

Product MSDS

https://www.bosterbio.com/msds?sku=EK0817

Other Gene Names

KLK5

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein Name

Kallikrein-5

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