Agatolimod

Agatolimod (ODN 2006), a class B ODN (oligodeoxynucleotide), is a TLR9 agonist. Agatolimod is also an optimal CpG sequence for humans. Agatolimod stimulates very strong production of NO2 and IL-6 in HD11 cells. Agatolimod can be used for breast cancer research. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'[1][2].

Product Specifications

CAS Number

[525625-52-9]

Product Name Alternative

ODN 2006; PF-3512676; CpG 7909; ODN 7909

UNSPSC

12352208

Target

Toll-like Receptor (TLR)

Type

Oligonucleotides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/agatolimod.html

Purity

98.49

Smiles

[Agatolimod]

Molecular Formula

C236H326N70O133P23S23

Molecular Weight

7699

References & Citations

[1]Xie H, et al. CpG-induced immunomodulation and intracellular bacterial killing in a chicken macrophage cell line. Dev Comp Immunol. 2003 Oct;27 (9) :823-34.|[2]Babaer D, et al. Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells. Cancers (Basel) . 2019 May 14;11 (5) :672.