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Anti-NF68 Nefl Antibody (Monoclonal, NR4)

Boster Bio Anti-NF68 Nefl Antibody (Monoclonal, NR4) catalog # MA1070. Tested in IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Pig, Rat.

Product Specifications

Background

Neurofilaments are composed of 3 neuron-specific proteins with apparent molecular masses of 68 kD (NFL), 125 kD (NFM) and 200 kD (NFH) on SDS-gel electrophoresis. And they have a role in the maturation of regenerating myelinated axons. Neurofilament 68 (NF68), also called Neurofilament Protein, Light Chain (NFL) . It is one of the most abundant cytoskeletal components of the neuron. Mutations in this gene were reported as a cause for autosomal dominant Charcot-Marie-Tooth type 2E (CMT2E) linked to chromosome 8p21. NFL was identified repeatedly in both screenings and found to interact with Myotubularin-related 2 gene, MTMR2 in both Schwann cells and neurons.

Synonyms

Neurofilament light polypeptide; NF-L;68 kDa neurofilament protein; Neurofilament triplet L protein; Nefl; Nf68, Nfl

Gene Name

Neurofilament light polypeptide

UniProt

P19527

Host

Mouse

Reactivity

Human, Mouse, Pig, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Pig spinal cord.

Clonality

Monoclonal

Clone

Clone: NR4

Tissue Specificity

Muscle specific. Located in the thin filament of striated muscle.

Applications

IHC, IHC-F, WB

Field of Research

Cell Type Marker, Cytoskeleton, Cytoskeleton/ECM, Developmental Biology, Intermediate Filaments, Lineage Markers, Lineage Specification, Neurodegenerative Disease, Neurology Process, Neuron Marker, Neuroscience, Signal Transduction, Stem Cells

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=MA1070

Product MSDS

https://www.bosterbio.com/msds?sku=MA1070

Fragment

Mouse IgG1

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 2-4μg/ml, Human, mouse, pig, rat, By Heat <br>Immunohistochemistry (Frozen Section), 2-4μg/ml, Human, mouse, pig, rat, -<br>Western blot, 1-2μg/ml, Human, mouse, pig, rat<br>

Other Gene Names

NEFL

Subcellular Location

Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton.

Sequence Similarities

Belongs to the intermediate filament family.

Protein Name

Neurofilament light polypeptide

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