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Anti-P-GlycoProtein (MDR) ABCB1 Antibody (Monoclonal, F4)

Boster Bio Anti-P-GlycoProtein (MDR) ABCB1 Antibody (Monoclonal, F4) catalog # MA1060. Tested in IHC, ICC, WB applications. This antibody reacts with Human.

Product Specifications

Background

P-Glycoprotein, , also known as Multidrug Resistance 1 (MDR1), is one of the ATP-binding cassette transporters family. P-glycoprotein-1 is involved in the transport of 3 of these protease inhibitors in vitro. MDR1 gene is mapped to the 7q21.1 by in situ hybridization. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.

Synonyms

Multidrug resistance protein 1A;3.6.3.44; ATP-binding cassette sub-family B member 1A; MDR1A; Multidrug resistance protein 3; P-glycoprotein 3; Abcb1a; Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3

Gene Name

DNA helicase

UniProt

P08183

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Mixture of human and hamster drug-resistant whole cells and crude plasma membranes.

Clonality

Monoclonal

Clone

Clone: F4

Tissue Specificity

ABCB1: Expressed in liver, kidney, small intestineand brain.

Applications

IHC, ICC, WB

Field of Research

ATPases, Cancer, Lipid Metabolism, Metabolism, Nuclear Import/Export, Plasma Membrane, Protein Trafficking, Signal Transduction

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. .

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=MA1060

Product MSDS

https://www.bosterbio.com/msds?sku=MA1060

Fragment

Mouse IgG1

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 1-2μg/ml, Human, By Heat <br>Immunocytochemistry , 1μg/ml, Human, -<br>Immunohistochemistry (Frozen Section), 1-2μg/ml, Human, -<br>Western blot, 0.5-1μg/ml, Human<br>

Other Gene Names

Abcb1a

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Protein Name

DNA replication licensing factor MCM7

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